Protein conservation and variability of signaling proteins having somatic and those having germline mutations.

<p>(<b>A</b>) Protein conservation associated with signaling proteins carrying somatic disease mutations is significantly higher than for proteins with germline mutations. (<b>B</b>) The protein conservation distribution is split into five approximately equal bins (Q) and the relative number of somatic (red line) and germline (blue line) mutations associated with proteins in each bin is computed. As a comparison the respective values for all reported SNPs from UniProt are shown (gray line). (<b>C</b>) Protein variability associated with signaling proteins carrying germline disease mutations is significantly higher than for proteins with somatic mutations. (<b>D</b>) Proteins are binned according to their variability and the relative number of somatic (red line) and germline (blue line) mutations, as well as all SNPs (gray line), is shown for each respective bin.