In microdissected colon samples the <i>GAS5</i>-derived snoRNAs are expressed more in malignant and pre-malignant tissue than benign tissue and levels correlate with p53 expression.

<p>A, RT-qPCR was used to measure the relative expression levels of miR-34a, snoRNA U44 and snoRNA U47 in microdissected human tissue samples corresponding to normal colorectal tissue (N), colorectal adenoma (A) and colorectal tumours (T) (Student's t test *P<0.05,**P≤0.006,***P≤0.0005). B, A Pearson's correlation analysis was performed to determine the relationship between miR-34a levels and the snoRNAs U44 and U47 in microdissected colorectal FFPE tumour tissue samples.