Overexpression of SOX2 protein in ovarian cancer is correlated with tumor metastasis and prognosis.

<p>(<b>A</b>), (<b>B</b>)Represent two examples of 64 cases. Among A, the upper left represents a primary cancer tissue;the lower left represents the corresponding metastases (omentum). Right, magnification of tissues in black frame. The arragement of B is similar to A. (<b>C)</b>, (<b>D</b>) Kaplan-Meier survival curves analysis shows subject with high SOX2 expression level have greater risk for death. Ovarian cancer tissues with SOX2 expression(score≥3) were classified as SOX2 high level. Among C, Patients with SOX2 high level(n = 43) had significantly worse survival than those with SOX2 low level(n = 21) in SOC primary tissue(<i>p</i> = 0.0358, log-rank test). Among D, Patients with SOX2 high level(n = 49) had significantly worse survival than those with SOX2 low level(n = 15) in SOC metastatic tissue(<i>p</i> = 0.0029, log-rank test).