Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
- Ioannidis, John P. A.
- Ng, Mandy Y.
- Sham, Pak C.
- Zintzaras, Elias
- Lewis, Cathryn M.
- Deng, Hong-Wen
- Econs, Michael J.
- Karasik, David
- Devoto, Marcella
- Kammerer, Candace M.
- Spector, Tim
- Andrew, Toby
- Cupples, L. Adrienne
- Duncan, Emma L,
- Foroud, Tatiana
- Kiel, Douglas P.
- Koller, Daniel
- Langdahl, Bente
- Mitchell, Braxton D.
- Peacock, Munro
- Recker, Robert
- Shen, Hui
- Sol-Church, Katia
- Spotila, Loretta D.
- Uitterlinden, Andre G.
- Wilson, Scott G.
- Kung, Annie W. C.
- Ralston, Stuart H.
DOIAbstract
Several genome-wide scans have been performed to detect loci that regulate BMD, but these have yielded inconsistent results, with limited replication of linkage peaks in different studies. In an effort to improve statistical power for detection of these loci, we performed a meta-analysis of genome-wide scans in which spine or hip BMD were studied. Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manne
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