Osteoblasts lacking Vhl promote BMSC proliferation.

<p>(A) Representative histological sections of distal femurs from 3-week-old OC-Cre: Vhl^flox/flox (CKO) and littermate control (CON) mice after staining with antibodies against PCNA as described in Methods. Sections were counterstained with methyl green. Original magnification, ×200. (B) Quantitative analysis of A. (C) CCK-8 test of BMSCs cultured with CMs. Data represent mean ± SD. *,p<0.05; **,p<0.01, ***,p<0.001.