<p>Representative images from G8 Ngn3<sup>EGFP/+</sup> mice are shown immunostained for Ngn3, identified by EGFP-positivity (red), and either insulin (green), glucagon (green), somatostatin (green), GLUT2 (green), Pdx-1 (green), or Ki67 (green) staining. Islets are outlined in white. Red arrows points to Ngn3-EGFP+ cells, green arrows points to hormone-positive cells, yellow arrows points to Ngn3-EGFP+ cells that co-localizes with either a hormone, GLUT2, Pdx-1 or Ki67.</p
<p>White arrows indicate insulin/DAPI co-positive pancreatic duct cells. Green arrows indicate insul...
<p>A–D: H&E-staining (A and B) and immunohistochemical analysis of synaptophysin expression (C and D...
<p>Images show immuno-stainings for insulin (<b>A</b>, <b>B</b>), glucagon (<b>C</b>, <b>D</b>), and...
<p><b>A)</b> Percentage of cells in the pancreatic islets of Ngn3:EGFP mice stained positive for EGF...
<p>mRNA expression of upstream regulators (Pdx-1, Sox9, and Hes-1,) and downstream targets (Tle3, Ne...
<p>Representative pictures of immunohistochemical analyses performed on pancreas sections from untre...
<p>(<b>A–F</b>) The investigation of the expression of the pro-endocrine marker <i>Ngn3</i> in anima...
<p>Co-staining for gastrin (red) and the progeny of Ngn3<sup>+</sup> cells (anti-GFP, green) in Ngn3...
<p>(A, B) Schematic of the alleles and transgenes for <i>Nkx6.1</i> inactivation and lineage tracing...
In order to define the molecular mechanisms regulating the specification and differentiation of panc...
<p>Images in panels A–H are from E15.5 mouse embryos. Arrows indicate cells co-expressing gastrin an...
The production of pancreatic β cells is the most challenging step for curing diabetes using next-gen...
<p><b>A-H</b>, Immunohistochemical staining of histologically normal tissue from living subjects und...
The delineation of regulatory networks involved in early endocrine pancreas specification will play ...
<p>White arrows indicate insulin/Ki67/DAPI co-positive cells. (B) The percentage of insulin/Ki67 co-...
<p>White arrows indicate insulin/DAPI co-positive pancreatic duct cells. Green arrows indicate insul...
<p>A–D: H&E-staining (A and B) and immunohistochemical analysis of synaptophysin expression (C and D...
<p>Images show immuno-stainings for insulin (<b>A</b>, <b>B</b>), glucagon (<b>C</b>, <b>D</b>), and...
<p><b>A)</b> Percentage of cells in the pancreatic islets of Ngn3:EGFP mice stained positive for EGF...
<p>mRNA expression of upstream regulators (Pdx-1, Sox9, and Hes-1,) and downstream targets (Tle3, Ne...
<p>Representative pictures of immunohistochemical analyses performed on pancreas sections from untre...
<p>(<b>A–F</b>) The investigation of the expression of the pro-endocrine marker <i>Ngn3</i> in anima...
<p>Co-staining for gastrin (red) and the progeny of Ngn3<sup>+</sup> cells (anti-GFP, green) in Ngn3...
<p>(A, B) Schematic of the alleles and transgenes for <i>Nkx6.1</i> inactivation and lineage tracing...
In order to define the molecular mechanisms regulating the specification and differentiation of panc...
<p>Images in panels A–H are from E15.5 mouse embryos. Arrows indicate cells co-expressing gastrin an...
The production of pancreatic β cells is the most challenging step for curing diabetes using next-gen...
<p><b>A-H</b>, Immunohistochemical staining of histologically normal tissue from living subjects und...
The delineation of regulatory networks involved in early endocrine pancreas specification will play ...
<p>White arrows indicate insulin/Ki67/DAPI co-positive cells. (B) The percentage of insulin/Ki67 co-...
<p>White arrows indicate insulin/DAPI co-positive pancreatic duct cells. Green arrows indicate insul...
<p>A–D: H&E-staining (A and B) and immunohistochemical analysis of synaptophysin expression (C and D...
<p>Images show immuno-stainings for insulin (<b>A</b>, <b>B</b>), glucagon (<b>C</b>, <b>D</b>), and...