Gender dimorphism of cardiac dysfunction was blunted in response to high dose of LPS (9 mg/kg)/PepG (1 mg/kg) co-administration.

<p>Panel <b>A</b>–<b>D</b>: Male or female mice received either LPS (9 mg/kg)/PepG (1 mg/kg) or PBS intraperitoneally. Cardiac function was assessed at 18 hours. (<b>A</b>) Representative M-mode echocardiograms; percentage (%) (<b>B</b>) ejection fraction (EF); (<b>C</b>) fractional shortening (FS); and (<b>D</b>) fractional area of change (FAC). The following groups were studied: Male+vehicle (n = 5); Female+vehicle (n = 4); Male+LPS/PepG (n = 11); Female+LPS/PepG (n = 6). Data are expressed as means ± SEM for n number of observations. ★<i>P</i><0.05 versus the respective sham group, #<i>P</i><0.05 versus male LPS/PepG group.