<p>Localization of TDP-43 in motor neurons of VLE and control mice sacrificed at 9, 18 and 24 months old (A, B, C). At each age there is an increase in the amount of motor neurons that demonstrate translocation of TDP-43 out of the nucleus into the cytoplasm in the VLE mice as compared to the control animals. These differences are statistically significant at each age at p<0.05. When only the VLE is shown over time (D) the increased percentage of motor neurons demonstrating translocation of TDP-43 is evident.</p
Mutations in TDP-43 cause amyotrophic lateral sclerosis (ALS), a fatal paralytic disease characteriz...
Mutations in the gene encoding the RNA-binding protein TDP-43 cause amyotrophic lateral sclerosis (A...
TDP-43 is pathologically and genetically with associated amyotrophic lateral sclerosis and frontotem...
<p>TDP-43 (green) immunoreactivity is shown in the anterior horn (AH) cells of mouse spinal cords. (...
<p>(<b>A</b>) Representative confocal images of mouse anterior horns of the spinal cord (AH) at 6 mo...
<p>Characterization of TDP-43 staining in a 673 day old VLE mouse. [A] Motor neuron with normal TDP-...
<p>Motor neuron numbers in the lumbosacral spinal cord a progressive reduction over time in the VLE ...
<p>Transgenic mice expressing hTDP-43<sup>A315T</sup> mutant at 6 months of age were i.p. injected w...
<p>(<b>a</b>-<b>e</b>) Analysis of Tc1 mice and WT littermate controls at the indicated ages (n = 4 ...
TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoprote...
The nuclear transactive response DNA-binding protein 43 (TDP-43) undergoes relocalization to the cyt...
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lowermotor neurons. ...
Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been re...
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lowermotor neurons. ...
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lower motor neurons....
Mutations in TDP-43 cause amyotrophic lateral sclerosis (ALS), a fatal paralytic disease characteriz...
Mutations in the gene encoding the RNA-binding protein TDP-43 cause amyotrophic lateral sclerosis (A...
TDP-43 is pathologically and genetically with associated amyotrophic lateral sclerosis and frontotem...
<p>TDP-43 (green) immunoreactivity is shown in the anterior horn (AH) cells of mouse spinal cords. (...
<p>(<b>A</b>) Representative confocal images of mouse anterior horns of the spinal cord (AH) at 6 mo...
<p>Characterization of TDP-43 staining in a 673 day old VLE mouse. [A] Motor neuron with normal TDP-...
<p>Motor neuron numbers in the lumbosacral spinal cord a progressive reduction over time in the VLE ...
<p>Transgenic mice expressing hTDP-43<sup>A315T</sup> mutant at 6 months of age were i.p. injected w...
<p>(<b>a</b>-<b>e</b>) Analysis of Tc1 mice and WT littermate controls at the indicated ages (n = 4 ...
TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoprote...
The nuclear transactive response DNA-binding protein 43 (TDP-43) undergoes relocalization to the cyt...
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lowermotor neurons. ...
Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been re...
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lowermotor neurons. ...
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lower motor neurons....
Mutations in TDP-43 cause amyotrophic lateral sclerosis (ALS), a fatal paralytic disease characteriz...
Mutations in the gene encoding the RNA-binding protein TDP-43 cause amyotrophic lateral sclerosis (A...
TDP-43 is pathologically and genetically with associated amyotrophic lateral sclerosis and frontotem...