Lumbar spinal cord TDP-43 Immunohistochemistry.

<p>Characterization of TDP-43 staining in a 673 day old VLE mouse. [A] Motor neuron with normal TDP-43 distribution: a darkly stained nucleus and an even, lightly stained cytoplasm graded as a zero. [B] Demonstrates mixed localization with redistribution of TDP-43 into diffuse cytoplasmic staining with reduced label in the nucleus and is graded as a one. [C] Demonstrates motor neuron with redistribution of TDP-43 into punctate staining in the cytoplasm and nucleus and is scored as a two.