Bivariate GCTA estimates of the genetic and residual correlations for bone mineral density measurements at the total-body less head, lower limb, upper limb and skull for the ALSPAC cohort.
- John P. Kemp (152856)
- Carolina Medina-Gomez (152852)
- Karol Estrada (149937)
- Beate St Pourcain (116086)
- Denise H. M. Heppe (152877)
- Nicole M. Warrington (102078)
- Ling Oei (580426)
- Susan M. Ring (116089)
- Claudia J. Kruithof (152891)
- Nicholas J. Timpson (111625)
- Lisa E. Wolber (167496)
- Sjur Reppe (152868)
- Kaare Gautvik (580427)
- Elin Grundberg (116416)
- Bing Ge (42609)
- Bram van der Eerden (580428)
- Jeroen van de Peppel (580429)
- Matthew A. Hibbs (131766)
- Cheryl L. Ackert-Bicknell (177934)
- Kwangbom Choi (580430)
- Daniel L. Koller (215373)
- Michael J. Econs (580431)
- Frances M. K. Williams (108925)
- Tatiana Foroud (28853)
- M. Carola Zillikens (152896)
- Claes Ohlsson (1924)
- Albert Hofman (107303)
- André G. Uitterlinden (2213413)
- George Davey Smith (82619)
- Vincent W. V. Jaddoe (122937)
- Jonathan H. Tobias (152918)
- Fernando Rivadeneira (61551)
- David M. Evans (152874)
DOIAbstract
<p>TBLH-BMD = total body less head BMD, (LL-BMD) = lower limb BMD, (UL-BMD) = upper limb BMD, (SK-BMD) = skull BMD, r<sub>g</sub> = genetic correlation between trait 1 and trait 2. r<sub>e</sub> = residual correlation between trait 1 and trait 2. All traits, excluding SK-BMD were adjusted for age, gender and weight. SK-BMD was adjusted for age, gender and height. <i>P</i>-refers to the <i>P</i>-value for the likelihood ratio test of whether r<sub>g</sub> = 0. Phenotypic correlations (r<sub>p)</sub> were as follows: SK-BMD/TBLH-BMD (r<sub>p</sub> = 0.40, SE = 0.013, P<0.001), SK-BMD/LL-BMD (r<sub>p</sub> = 0.31, SE = 0.013, P<0.001), SK-BMD/UL-BMD (r<sub>p</sub> = 0.40, SE = 0.013, P<0.001) and LL-BMD/UL-BMD (r<sub>p</sub> = 0.64, SE = 0.010...
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