Respiratory control ratios (RCR's) in mitochondria isolated from TA muscle of lean and diabetic rats treated with water or 30, 100 or 300 mg/kg body weight/day metformin (MET30, MET100 and MET300, respectively) for 2 weeks, fueled by pyruvate plus malate (Complex I-dependent substrate) and succinate plus rotenone (Complex II-dependent substrate).

<p>Data is represented as mean ± SD (n = 6 per group). For the RCR with pyruvate, the interaction between genotype and treatment was significant and a pairwise analysis of differences is provided by Bonferroni-corrected two-sided unpaired t-tests: ^# P<0.05 when compared with lean animals of the same treatment regimen,^† P<0.05 when compared with MET30-treated animals of the same genotype.