Sleep-related changes in arterial pressure, heart rate, cardiovagal modulation, and cardiac baroreflex sensitivity.

<p>Panels A-D show the mean values of MAP and HR, pNN8 (an index of cardiac vagal modulation), and spontaneous cardiac baroreflex sensitivity (BRS) during epochs of WAKE, non-rapid-eye-movement sleep (NREMS) and rapid-eye-movement sleep (REMS) averaged over 48 hours including light and dark periods. Data are means ± SEM for KO and WT mice fed a SD or a HFD, with n = 9–10 per group. The [†] symbol indicates a significant main effect of diet (<i>P</i><0.05, ANOVA). Horizontal brackets indicate significant pairwise comparisons (<i>P</i><0.05, <i>t</i>-test). For other abbreviations and symbols see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100536#pone-0100536-g001" target="_blank">Figure 1</a>. Detailed ANOVA results are reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100536#pone.0100536.s003" target="_blank">Table S2</a>.