PTPRT KO mice are resistant to high-fat diet-induced body composition changes.

<p>A) Five week-old male mice of <i>Ptprt</i>^+/+ (n = 8), <i>Ptprt</i>^+/− (n = 14) and <i>Ptprt</i>^−/− (n = 11) genotypes were fed with high-fat diet for 14 weeks. Body weight of the three genotypes was assessed weekly. (*<i>p</i><0.05; t-test comparing <i>Ptprt</i>^+/+ and <i>Ptprt</i>^−/− genotypes). B–D) Body composition was analyzed by quantitative magnetic resonance after 14 weeks on a high-fat diet (Fat % – B, Lean % – C, Water % – D; *<i>p</i><0.05; t-test comparing <i>Ptprt</i>^+/+ and <i>Ptprt</i>^−/− genotypes; t-test comparing <i>Ptprt</i>^+/− and <i>Ptprt</i>^−/− genotypes was not significant).