Synteny and phylogenetic analysis.

<p>A. Comparative gene location of IFIT sequences between human chromosome 10 and zebrafish chromosomes 5, 12, 13 and 17. The genes flanking the IFIT cluster, located at the q23.31 region of human chromosome 10, showed a high degree of synteny with the zebrafish chromosomes 17 and 12. Moreover, the genes surrounding zebrafish IFIT 13 were located on the same human chromosome but in the q22.2 region. An IFIT sequence was also present on zebrafish chromosome 5. B. Phylogenetic relationship between the IFIT proteins from bony fish and similar proteins described in other vertebrates, such as amphibians, birds and mammals. Lch: <i>Latimeria chalumnae</i>; Om: <i>Oncorhynchus mykiss</i>; Sas: <i>Salmo salar</i>; Ca: <i>Carassius auratus</i>; Ci: <i>Ctenopharyngodon idella</i>; Lc: <i>Larimichthys crocea</i>; Dl: <i>Dicentrarchus labrax</i>; Tn: <i>Tetraodon nigroviridis</i>.