Coherent averaging of spontaneous surges of arterial pressure.

<p>The panels show time series of ΔSAP (A, C, E) and ΔHP (B, D, F) during spontaneous SAP surges (detection threshold = 5 mm Hg) during WAKE, NREMS, and REMS over 48 hours including light and dark periods. The time series were normalized by subtracting the respective baseline values and synchronized at the SAP peak. Panel G summarizes the interpretation <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100536#pone.0100536-Silvani4" target="_blank">[22]</a>. A ΔHP trough (i.e., cardiac acceleration) preceding a SAP surge is consistent with central autonomic control of the heart. A positive ΔHP peak (i.e., cardiac slowing) following a SAP surge is consistent with baroreflex cardiac control. Statistical analysis in panels A–F was performed on ΔSAP and ΔHP peaks and the ΔHP nadir. Panel H shows the frequency of spontaneous SAP surges per 10 min of each wake-sleep state. Data are means ± SEM for KO and WT mice fed a SD or a HFD, with n = 9–10 per group. Detailed ANOVA results are reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100536#pone.0100536.s005" target="_blank">Table S4</a>. For abbreviations and symbols see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100536#pone-0100536-g001" target="_blank">Figures 1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100536#pone-0100536-g003" target="_blank">3</a>.