DNA segregation errors correlate with multinucleation.

<p>[A] HeLa cells infected with L2, MoPn or GPIC for 40 hours. Cells were stained with anti-β-tubulin (green), human serum (red), and Draq5 (blue). Nuclei are noted with asterisks and DNA bridging is identified with the arrow. [B] Cells exiting mitosis were evaluated for DNA bridges and lagging chromosomes. L2 infected cells show the largest increase in DNA segregation errors while GPIC infectected cells show the least. Infection with any of the three species lead to significantly higher rates of DNA segregation errors from uninfected (T-test, p<0.01) N = 3 experiments with ≥100 cells per experiment. Rates of DNA segregation errors induced by each species also varied significantly from one another (T-test, p<0.01). Bar on images = 5 nm.