Hepatoma cells were inhibited by HBO, sorafenib, cisplatin and their combinations

<p>. (A) BEL-7402 cells were treated with HBO, sorafenib or sorafenib+HBO for one week. Cell proliferation was determined by CCK8 at indicated times (n = 5 for each treatment). The combination of HBO and sorafenib resulted in a marked synergistic growth inhibition in hepatoma cells. Values represent mean ± SD; *<i>P</i><0.05, ***<i>P</i><0.001, when compared with the blank group. (B) In BEL-7402 cells, the same synergistic growth inhibition induced by cisplatin and HBO was observed. (C) and (D) In SK-Hep1 cells, synergistic growth inhibition was also induced by the combination of HBO and sorafenib (C) or of HBO and cisplatin (D).