Evaluation of Glutathione S-transferase T1 (GSTT1) deletion polymorphism on type 2 diabetes mellitus risk in a sample of Yazdian females in Yazd, Iran

<p>Background: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of<br>diabetes mellitus (DM). The aim of this study was to assess the possible association between genetic polymorphisms<br>of the glutathione S-transferase-mu (GSTT1) and the risk of the development of DM in a sample of Yazdian females<br>in Yazd, Iran.<br>Methods: This was a case-control study in which GSTT1 polymorphism was genotyped in 51 randomly selected<br>DM patients and 50 randomly selected healthy controls among Yazdian females whose ages ranged from 40 to 70.<br>Results: The frequencies of GSTT1 null genotype and GSTT1 present were 8 and 92%, respectively, in the control<br>samples. In patients with type 2 diabetes (T2DM), the frequencies of GSTT1 null genotype and GSTT1 present were<br>14 and 86%, respectively. There were higher levels of triglycerides (TG), fasting blood sugar (FBS), total<br>cholesterol (TC), low density lipoprotein (LDL), body mass index (BMI), and high density lipoprotein (HDL) in<br>patients with GSTT1 null genotype than in patients with the GSTT1 present genotype.<br>Conclusions: Our results indicated that the GSTT1 deletion polymorphism is a risk factor for T2DM. We did not<br>determine any significant association between the GSTT1 null genotype and T2DM.</p> <p>