Mice have decreased their jejunal levels of anorectic NAE after oleic acid-HFD to the same extend as when fed olive oil-HFD.

<p>Male C57Bl6 mice were fed 7 days with 45E% oleic acid- or olive oil-HFD, respectively. One group receiving olive oil-HFD was also pair fed with the oleic acid-HFD group. Jejunum from the mice were isolated and analyzed for NAEs and NAPEs. A) NAE levels are expressed as percentage of control ± SEM. 100% PEA = 291 pmol/g tissue, 100% OEA = 649 pmol/g tissue, 100% LEA = 1838 pmol/g tissue. B) NAPE levels as percentage of control ± SEM 100% 16∶0 NAPE = 1265 pmol/g tissue, 100% 18.1 NAPE = 473 pmol/g tissue, 100% 18∶2 NAPE = 1531 pmol/g tissue. N = 7–8 animals per group. C) 7 days of accumulated food intake normalized to body weight. D) Body fat mass at baseline and at termination. *p<0.05, **p<0.01, ***p<0.001 1-way ANOVA corrected with Holm Bonferroni test, followed by Fisher's PLSD post hoc test.