Effect of MK-0626 on pancreatic islet morphology and size during tacrolimus-induced injury.

<p>Immunohistochemistry for insulin showing pancreatic islet morphology and size in the experimental groups. Well-preserved pancreatic islet structure and insulin-immunoreactivity areas are seen in the control alone and MK-0626 (M) groups. The tacrolimus (TAC) group showed a smaller size of islet with lower intensity of insulin staining within islet than control group. In contrast, additional treatment of MK-0626 reversed these changes (A). Quantitative analysis of islet area. Note the significant lower islet area in the TAC+M10 and TAC+M20 groups than in the TAC group (B). Original magnifications, x 400. <i>n</i> = 8 rats per group, ^#P<0.05 vs. control. ^$P<0.05 vs. TAC.