Effect of MK-0626 on TAC-induced pancreatic islet dysfunction.

<p>(A) Intraperitoneal glucose tolerance test (IPGTT). (B) The area under the curve for glucose (AUCg). (C) Plasma insulin level. (D) Hemoglobin A1c (HbA1c). (E) Homeostatic model assessment of insulin resistance (HOMA-IR) index. Note that all parameters are recovered after combined treatment with MK-0626 (M) and tacrolimus (TAC). <i>n</i> = 8 rats per group. ^#P<0.05 vs. Control. ^$P<0.05 vs. TAC, *P<0.05 vs. other groups.