Effect of MK-0626 on apoptosis during tacrolimus-induced pancreatic islet injury.

<p>In situ TdT-mediated dUTP–biotin nick end labeling (TUNEL) assay (A) and its analysis (B) to detect apoptosis in pancreatic islets in the experimental groups. MK-0626 (M) treatment significantly reduces TUNEL-positive cells (arrows) compared with tacrolimus (TAC) group. (C) Quantitative analysis in islets of the active form of caspase-3 in the experimental groups. Note that the MK-0626 treatment significantly reduced active caspase-3 compared with the TAC group. Original magnifications, x400. <i>n</i> = 8 rats per group. ^#P<0.05 vs. control. ^$P<0.05 vs. TAC.