Femoral trabecular analysis of PPS-treated MPS VI rats.

<p>MicroCT analysis of the femurs was performed as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100882#s2" target="_blank">Materials and Methods</a>. Representative images are shown for 7-month-old (<b>A</b>) normal, (<b>B</b>) untreated MPS VI, (<b>C</b>) 1 mg/kg, (<b>D</b>) 2 mg/kg, and (<b>E</b>) 4 mg/kg sc PPS-treated animals. Black arrows indicate the trabecular regions. MicroCT quantification of the trabeculae is shown below the images. Dose responsive improvements in several criteria were observed, including % bone volume/tissue volume (BV/TV), bone surface/volume ratio (BS/BV), trabecular number (Tb.N), trabecular separation (Tb.Sp), total porosity Po(tot), and bone mineral density (BMD). *indicates statistical differences between untreated and treatment groups (p<0.05).