Liver-specific genes show more dispersion and upregulation than other endodermal tissue-specific genes.

<p>Genes annotated as specific to an endodermal tissue, placenta (proxy for cellular immaturity), or soft-tissue (proxy for fibroblasts) were taken from the TiGER database and plotted on a scatterplot (A), with up or down facing triangles indicating significant up or downregulation respectively. As indicated by the lower R² value, liver-specific genes were highly dispersed away from control compared to other developmentally related endodermal tissues, such as pancreas. (B) Tissue-specific genes up or downregulated more than 2-fold were displayed as bars. Genes are grouped by tissue and ranked by expression level. Tissues were ordered based on the positive logarithmic area under the curve. The majority of dispersion of liver-specific genes resulted from upregulations. Other endodermal tissues were upregulated and downregulated proportionally. Soft tissue genes were primarily downregulated.