Altered Brain Volumes in 6 Month Old Female Offspring Brain.

<p>Regions of interest were analyzed by 1-way ANOVA in 6 month old female mice offspring born to pregnant CD1 mice injected either with an adenovirus carrying sFlt-1 or adenovirus carrying mFc fragment. Mice injected with sFlt-1 were treated with either pravastatin or water to result in three groups of offspring animals: mFc (n = 6), sFlt-1 (n = 3), and sFlt-1-pra (n = 10). Data are reported as mean ± SEM. The sFlt-1 group offspring showed decreased volumes at the inferior colliculus (A; p = 0.04), thalamus (B; p<0.0001), and lateral globus pallidus (C; p = 0.02) when compared to the mFc control offspring. Increased volumes were seen at the stria medullaris (D; p = 0.01), and fasciculus retroflexus (E; p = 0.01). The overall ameliorative effect of pravastatin exposure in utero is seen. Not shown are brain regions with similar volumes between groups.