Bcl-2 receptor binding profiles of 36 BH3-like peptides from human proteins.

<p>Binding profiles for known BH3 peptides interacting with Bcl-x_L, Bcl-w, Bcl-2, Mcl-1 and Bfl-1, measured by Certo et al., are in the left panel <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003693#pcbi.1003693-Certo1" target="_blank">[10]</a>. 34 peptides identified in this study with K_D<10⁴ nM for binding to at least one of five prosurvival proteins are in the right panel; these are ordered from left to right according to binding affinity, as indicated in the greyscale key. See <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003693#pcbi.1003693.s005" target="_blank">Table S3</a> for the K_D values used for binning and 95% confidence intervals.