αGalCer analog PBS57 effects are strain dependent, improving disease in BALB/c.

<p><b>A.</b> Ear lesion volumes of wild type BALB/c mice infected with low dose promastigotes and receiving 100 ng or 2000 ng at the time point of infection or 100 ng at the time point of infection and 6 weeks later. Significance is indicated as compared to control mice. <b>B.</b> Parasite burdens measured in the ear and spleen of control or 100 ng αGalCer analog PBS57 treated mice at week 5 and 8 post infection. <b>C.</b> Levels of IFNγ, IL-4 and IL-10 measured from lymphocytes restimulated with SLA, 5 and 8 weeks post infection. Results shown are from >1 experiment with a minimum of 4 animals per group. Significant differences between groups are labeled with *, **, and *** referring to p-values≤0.05, ≤0.005, and ≤0.002 respectively.