αGalCer analog PBS57 effects are dependent on dose and time of administration.

<p><b>A.</b> Ear lesion volumes of wild type C57BL/6 mice infected with low dose promastigotes and receiving 10, 100, or 2000 ng. <b>B.</b> Ear lesion volumes during the course of infection with 100 ng of αGalCer analog PBS57 applied at the time of infection, 6 weeks after infection, or at both time points. <b>C.</b> As in B, only here PBS57 was applied at 1 week before and 3 weeks after infection. Significant differences between groups at each time point are labeled with *, **, and *** referring to p-values≤0.05, ≤0.005, and ≤0.002 respectively (n = 2 independent experiments with ≥4 mice/group).