Electron microscopy of a foot tissue section showing a typical rhogocyte.

<p>(<b>A</b>) Overview of the rhogocyte. Note the large nucleus (→n), electron-dense granula (→g) and the abundant endoplasmic reticulum (→ER). (<b>B</b>) Enlargement of the region indicated by a black box in (A), showing that the endoplasmic reticulum (→ER) is lined with ribosomes (<i>i.e.</i> rough ER). Note in the adjacent ER lacuna the flocculate material that might be protein (→p). The insert in (B) shows a further enlargement of the region indicated by the black box in (B) to visualize individual ribosomes. (<b>C</b>) Enlargement of the region indicated by a white box in (A), showing several extracellular lacunae (→e) with cytoplasmatic bars (→b) and 20 nm slits (→s). In the bars, adjacent to the slits, electron-dense material is visible that was later shown to contain actin (→a). Also note the lamina of extracellular matrix (→m) and the coat (→c) lining the plasma membrane at the extracellular lacunae. In the adjacent cytoplasm, the protein-like material is seen (→p). The insert in (C) shows a further enlargement of the region indicated by a black box in (C) to visualize the slit diaphragm (→d) as two parallel small rods. Also note, in this insert, the actin-containing electron-dense material (→a) and the lamina of extracellular matrix (→m). The gully grate-like cytoplasmic bars are cut here in transversal section; for a longitudinal section, see Fig. 4B.