The GSH response to glucose reduction is unique to an individual patient.

<p>Individual response curves of diabetic patients obtained using the minimal model are shown (thin gray curves; n = 34, out of 49) together with an average profile (bold black curve). The population-averaged curve has a threshold (black dot) at glucose = 7.5 mmol/L and GSH approximately 364; = 728, and = 43.7. An inflection regime (width approximately one-fourth, 1.8 mmol/L) is marked in red; this is a transition phase between fully developed hyperglycemia and normoglycemia. The ADA impaired fasting glucose (IFG) range, 5.5–6.9 mmol/L glucose, is overlaid for reference; WHO-IFG is the WHO criterion, 6.1–6.9 mmol/L. It is interesting to note that IFG occupies the upper third of the red curve, and 8-week patients (above age 40; GSH between 220–480 nmoles/ml) lie in the lower portion of the red curve.