Sixteen functional single nucleotide polymorphisms (SNPs) in 13 genes involved in regulation of inflammation were found to be associated with susceptability of severe Crohn's disease (CD), ulcerative colitis (UC) or inflammatory bowel diseases (IBD).
- Steffen Bank (589032)
- Paal Skytt Andersen (331783)
- Johan Burisch (590117)
- Natalia Pedersen (590118)
- Stine Roug (590119)
- Julie Galsgaard (590120)
- Stine Ydegaard Turino (590121)
- Jacob Broder Brodersen (590122)
- Shaista Rashid (590123)
- Britt Kaiser Rasmussen (590124)
- Sara Avlund (590125)
- Thomas Bastholm Olesen (590126)
- Hans Jürgen Hoffmann (590127)
- Marianne Kragh Thomsen (589033)
- Vibeke Østergaard Thomsen (547738)
- Morten Frydenberg (346317)
- Bjørn Andersen Nexø (21238)
- Jacob Sode (589031)
- Ulla Vogel (21241)
- Vibeke Andersen (447795)
Publication date
June 2014
DOIAbstract
<p>Eleven of the SNPs have not previously been reported as susceptability polymorphisms of CD, UC or IBD (<i>TLR2</i> (rs4696480 and rs1816702), <i>TLR4</i> (rs1554973 and rs12377632), <i>TLR9</i> (rs187084 and rs352139), <i>LY96</i> (rs11465996), <i>NFKBIA</i> (rs696), <i>TNFRSF1A</i> (rs4149570), <i>IL6R</i> (rs4537545) and <i>PTPN22</i> (rs2476601)).</p
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