Biological functional categories of immune factors identified in saliva and rectal lavage fluid according to their gene ontology.

<p>Proteins identified in both rectal and salivary mucosal fluid pools were annotated by function using the UniprotKB database. Functional analysis found 72 of the 315 identified proteins had functions in immunity. The proportion of the total number of proteins known to possess each given function is displayed (proteins may be found under multiple categories if they have displayed more than one function). Differential expression analysis identified 49 proteins commonly expressed between fluids (grey), 15 overabundant proteins in rectal lavage (red) and 8 proteins underabundant in rectal lavage (green), relative to saliva (p<0.05, corrected for multiple comparisons). Differentially expressed proteins were found in multiple functional categories. The complete list is shown in in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100820#pone-0100820-t002" target="_blank">Tables 2a and 2b</a>. Functions of proteins that have no known role in immunity are included in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100820#pone.0100820.s002" target="_blank">Table S1</a>.