Putative sumo-interacting motifs (SIMs) in TRIM22.

<p><b>A</b>. List of putative SIMs in the TRIM22 protein, including the sequence and domain location for each SIM (amino acids are indicated in parentheses); Red and blue amino acids are predicted functional and structural residues, respectively (ConSurf analysis <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101436#pone.0101436.s001" target="_blank">Figure S1</a>); Asterisk: SIMs that are conserved in all mammalian TRIM22 orthologues except elephant; Double asterisk: SIMs that are not found in TRIM5α, but are replaced by a different SIM (e.g. VLTL, IVPL). <b>B</b>. Alignment of mammalian TRIM22, human TRIM5α, and rhesus monkey TRIM5α amino acid sequences (amino acids 350–444 of the B30.2 domain are shown). Conserved SIMs are highlighted in magenta and other SIMs are highlighted in light blue. Conserved amino acids are indicated with an asterisk.