<p>A: AGE accumulation (CML (left) and MG-AGE (right)) in MCF-7-Md (lower panel) and TamR-Md cells (upper panel) after cultivation for three days with different concentrations of methylglyoxal and glyoxal as shown by Western blotting. Strongly enhanced AGE accumulation became visible when cell number was significantly reduced due to toxic effects, as represented by the decreasing β-actin signal. Glyoxal resulted in accumulation of CML whereas methylglyoxal treatment caused MG-AGE modification. Cells were treated as described for the determination of vitality/proliferation. Proteins were extracted per well and not corrected for protein amount. Therefore, the blots represent adherent cells only. B) AGE accumulation shown by immunofluorescence...
Advanced glycation endproducts (AGEs) arise from the reaction of sugars with side chains and the N-t...
Methylglyoxal (MG) is quantitatively the most important precursor to advanced glycation end-products...
Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of...
Tatone C, Heizenrieder T, Di Emidio G, et al. Evidence that carbonyl stress by methylglyoxal exposur...
Advanced glycation endproducts (AGEs) are formed from the non-enzymatic interaction of reducing suga...
Methylglyoxal is a toxic by-product of glycolysis and amino acid metabolism in mammalian systems. Th...
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl compound, has be...
The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived ...
The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycat...
Methylglyoxal (MG), a metabolite of glucose, causes non-enzymatic glycation of proteins to form irre...
In the aging brain, cells undergo stress, inflammation, loss of replicative ability and in some case...
AbstractAdvanced glycation end products (AGEs) that arise from the reaction of sugars with protein s...
In recent years, glycative stress from exogenous or endogenous advanced glycation end products (AGEs...
International audienceMetabolic reprogramming toward aerobic glycolysis unavoidably induces methylgl...
Cardiovascular disease, caused predominantly by atherosclerotic plaque rupture, remains one of the l...
Advanced glycation endproducts (AGEs) arise from the reaction of sugars with side chains and the N-t...
Methylglyoxal (MG) is quantitatively the most important precursor to advanced glycation end-products...
Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of...
Tatone C, Heizenrieder T, Di Emidio G, et al. Evidence that carbonyl stress by methylglyoxal exposur...
Advanced glycation endproducts (AGEs) are formed from the non-enzymatic interaction of reducing suga...
Methylglyoxal is a toxic by-product of glycolysis and amino acid metabolism in mammalian systems. Th...
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl compound, has be...
The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived ...
The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycat...
Methylglyoxal (MG), a metabolite of glucose, causes non-enzymatic glycation of proteins to form irre...
In the aging brain, cells undergo stress, inflammation, loss of replicative ability and in some case...
AbstractAdvanced glycation end products (AGEs) that arise from the reaction of sugars with protein s...
In recent years, glycative stress from exogenous or endogenous advanced glycation end products (AGEs...
International audienceMetabolic reprogramming toward aerobic glycolysis unavoidably induces methylgl...
Cardiovascular disease, caused predominantly by atherosclerotic plaque rupture, remains one of the l...
Advanced glycation endproducts (AGEs) arise from the reaction of sugars with side chains and the N-t...
Methylglyoxal (MG) is quantitatively the most important precursor to advanced glycation end-products...
Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of...