Dysregulation of the PI3K/AKT and HIF-1pathways in Cox-2 deficient PDMPCs.

<p>Heat maps showing differentially expressed genes associated with the PI3K/AKT (A) and the HIF-1 pathway (B) in micromass cultures in the presence and absence of BMP-2 for seven days. Each column shows the relative gene expression of a sample for the indicated pathway-associated genes. RT-PCR analyses further quantitate the values for the key genes in the HIF-1 pathway at day 1 (white bars) and day 7 (black bars) (C), namely <i>VEGFA</i>, <i>EGLN1</i>, <i>EGLN3</i>, <i>HIF-1a</i> and <i>ANGPT4</i>. * p<0.05, as compared to the control.