The effects of inhibitors of EGF, VEGF and FGF signaling pathways on compound <b>10</b>-induced angiogenesis in VRI-treated zebrafish.

<p>The semi-quantitative analysis of effects of inhibitors on angiogenesis activity of 10 in VRI-treated zebrafish: ○, inactive, < 20% inhibition rate; ++++, > 80%; +++, 60–80%; ++, 40–60%; +, 20%–40% as compared to the <b>10</b> post-treated zebrafish embryos. ^aZebrafish embryos treated with the indicated concentration of inhibitor had been showed toxicity and the inhibitory effect was not determined.