Survival curves and bacillary burdens in the lungs, liver and spleen of C57BL/6 and P2X7R^−/− mice infected with hypervirulent mycobacteria.

<p>C57BL/6 and P2X7R^−/− mice were infected i.t. with approx. 100 bacilli of H37Rv <i>Mtb</i>, Beijing 1471 <i>Mtb</i> and MP287/03 <i>Mbv</i>. Non-infected mice were used as controls. (A) The infected mice were examined daily to determine the survival curves (<i>n</i> = 13–19). (B) The number of CFU/g of tissue was evaluated in the left lung, liver and spleen on day 28 p.i. (means ± SD, <i>n</i> = 9). Significant differences were observed for the indicated groups (*<i>p</i><0.05, **<i>p</i><0.01 and ***<i>p</i><0.001). The data are representative of three separate experiments.