Knockdown of <i>hif2-alpha</i> damages liver cell proliferation.

<p>WT (Tg(<i>lfabp</i>:EGFP)) embryos (A) and <i>hif2-alpha</i> ATG-MO-injected embryos (B) were examined for liver cell proliferation using an anti-pH3 antibody at 4 dpf. Cell proliferation in <i>hif2-alpha</i> ATG-MO-injected embryos was reduced compared with WT embryos. (C) Quantification of pH3-positive cells in the liver (n = 11, <i>p</i><0.05). (D) The EGFP-positive cells were counted by FACS. Quantification of pH3-positive cells in the trunk (E) and tail (F) (n = 4, <i>p</i><0.05).