<p>hMDMs were infected with Mtb H37Rv and uptake was determined (D0). Following infection, hMDMs were stimulated with PMNapo or Jurkatapo at a ratio of 2∶1. Measurements of Mtb by luminometry were performed at indicated time points. Data are presented as ratio compared to the initial bacterial load at D0 (<i>i.e.</i> increase in bacterial load) and the graphs show the mean <u>+</u> SEM (n = 5). Differences between groups are shown as * (p<0.05), ** (p<0.01) or *** (p<0.001).</p
<p>hMDMs were left untreated, or treated for 48h with 10 μg/ml of <i>H</i>. <i>diminuta</i> (H.d), <...
<p>(A) THP-1 cells, (B) MDM, or (C) AM were pretreated with 0.1% (v/v) DMSO (open squares) or 5 µM B...
<p>A. In parallel sets, THP-1 cells and primary human PBMC-derived macrophages (HuMφ were infected w...
<p>hMDMs were stimulated with γ-irr Mtb at a ratio of 5∶1 (Mtb) for one hour, with or without subseq...
<p>hMDMs were stimulated with γ-irr Mtb for one hour with or without subsequent stimulation with PMN...
<p>hMDMs were stimulated with FITC labeled γ-irr Mtb at a ratio of 5∶1 (Mtb), with subsequent stimul...
<p>hMDMs were pre-incubated with or without cytochalasin D (CytD) prior to stimulation with γ-irr Mt...
<p>hMDMs, with or without pre-incubation with Ac-YVAD-CMK (caspase-1 inhibitor), were stimulated wit...
hMDMs were infected at a MOI of 2 bacteria per cell for 2 h with the various strains. After infectio...
<p>(<b>A</b>) THP-1 cells were infected with <i>MTB</i> H37Rv for 4 and 8 days with or without BAY, ...
<p>(A) Raw264.7 cells were screened for induction of apoptosis using Annexin-V/PI staining after 48 ...
<p>(A) Comparative infectivity of WT and ΔESX-1 <i>Mtb</i>. BM-DC were infected with DsRed-WT or-ΔES...
<p>The percentage of <i>Mtb</i> containing phagosomes that contain Hv1 was assessed in quadruplicate...
<p>Apoptotic macrophages show TUNEL-positive nuclei stained green . Representative results are shown...
<p>(A and B) Expression of <i>rv2390c-rpfD</i> is upregulated during Mtb infection of activated vs. ...
<p>hMDMs were left untreated, or treated for 48h with 10 μg/ml of <i>H</i>. <i>diminuta</i> (H.d), <...
<p>(A) THP-1 cells, (B) MDM, or (C) AM were pretreated with 0.1% (v/v) DMSO (open squares) or 5 µM B...
<p>A. In parallel sets, THP-1 cells and primary human PBMC-derived macrophages (HuMφ were infected w...
<p>hMDMs were stimulated with γ-irr Mtb at a ratio of 5∶1 (Mtb) for one hour, with or without subseq...
<p>hMDMs were stimulated with γ-irr Mtb for one hour with or without subsequent stimulation with PMN...
<p>hMDMs were stimulated with FITC labeled γ-irr Mtb at a ratio of 5∶1 (Mtb), with subsequent stimul...
<p>hMDMs were pre-incubated with or without cytochalasin D (CytD) prior to stimulation with γ-irr Mt...
<p>hMDMs, with or without pre-incubation with Ac-YVAD-CMK (caspase-1 inhibitor), were stimulated wit...
hMDMs were infected at a MOI of 2 bacteria per cell for 2 h with the various strains. After infectio...
<p>(<b>A</b>) THP-1 cells were infected with <i>MTB</i> H37Rv for 4 and 8 days with or without BAY, ...
<p>(A) Raw264.7 cells were screened for induction of apoptosis using Annexin-V/PI staining after 48 ...
<p>(A) Comparative infectivity of WT and ΔESX-1 <i>Mtb</i>. BM-DC were infected with DsRed-WT or-ΔES...
<p>The percentage of <i>Mtb</i> containing phagosomes that contain Hv1 was assessed in quadruplicate...
<p>Apoptotic macrophages show TUNEL-positive nuclei stained green . Representative results are shown...
<p>(A and B) Expression of <i>rv2390c-rpfD</i> is upregulated during Mtb infection of activated vs. ...
<p>hMDMs were left untreated, or treated for 48h with 10 μg/ml of <i>H</i>. <i>diminuta</i> (H.d), <...
<p>(A) THP-1 cells, (B) MDM, or (C) AM were pretreated with 0.1% (v/v) DMSO (open squares) or 5 µM B...
<p>A. In parallel sets, THP-1 cells and primary human PBMC-derived macrophages (HuMφ were infected w...