Mean daily activity onsets following a 6/12D cycle for control and STZ-diabetic mice.

<p>(<b>A</b>) One representative actogram of locomotor activity for control and two for STZ-diabetic mice, double-plotted on a 24 h timescale. The numbered lines represent successive days and the bar above the actograms indicates the original light/dark cycle. After 17 days of entrainment under a 12L/12D cycle at 1000 lux, control and STZ-diabetic mice were exposed to a 6 h advanced light/dark cycle (black dot in the actograms) at 12 weeks post-diabetes. (<b>B</b>) Phase angle of photic entrainment. Control mice achieve stable re-entrainment after 8±0.2 days, whereas STZ-diabetic mice need 10.6±0.3 days (Diabetic-case 1; n = 6; p≤0.001). Certain STZ-diabetic mice (n = 4) display a less stable entrainment even after 20 days (Diabetic-case 2). Data are presented as means ± SEM (n = 10 for each group).