Temporal expression profiles of rhythmic and non-rhythmic genes.

<p>RNA levels of U2OS cells were analyzed in 3(0–45 h) relative to the average were calculated and plotted on a log2 scale versus the circadian time (CT). For each gene up to 10 probes were spotted on the arrays. Light blue lines correspond to expression profiles based on individual probes. The black triangles and the fitted dark blue sine curve correspond to the median of the data. Light and dark areas in the background indicate subjective day and night, respectively. Examples are shown for genes that fall in various categories. (<b>A</b>) Clock genes with CRBSs. (<b>B</b>) Clock-genes without CRBSs. (<b>C</b>) Rhythmic genes with CRBSs. (<b>D</b>) Rhythmic genes without CRBSs. (<b>E</b>) Genes not expressed in a rhythmic fashion. <i>AGAP11</i> harbors a highly enriched binding site for BMAL1, CLOCK, and CRY1, <i>CHP</i> has a CRY1 binding site. In both genes the CRBSs were close to the TSS. <i>CSNK2B</i> and <i>KDELR1</i> do not have a CRBS in a window of ±20 kb.