Filtered multiple-nephron fold concentration increase at 48 hours post-insult.

<p>Filtered biomarker concentration increases in Healthy, Hyperfiltering and CKD kidneys. Each line of iso-intensity represents the fold increase 48-hours following insult of a preformed biomarker relative to the pre-injury concentration in a Healthy Kidney with 2 million nephrons and a GFR of . Four GFR scenarios (no change in GFR [ for Healthy and Hyperfiltering kidneys, and for CKD kidney], one-third, one-half, and two-thirds reduction in GFR) were combined with four nephron number scenarios (no loss [2 M for Healthy, 1.33 M for Hyperfiltering, and 0.67 M for CKD kidneys], one-third, one-half, and two-thirds loss) to produce 16 scenarios. From each of these the fold increase in biomarker concentration at 48-hours following insult was extracted. The iso-intensity lines of fold increase were then interpolated. Each scenario from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101288#pone-0101288-g002" target="_blank">figure 2</a> is represented for no change in GFR, one-third, one-half, and two-thirds reduction. All scenarios are for a receptor production rate constant and loss rate constant .