p38α blockage does not affect bone resorption parameters.

<p>(A) <i>Rankl</i>, <i>Opg</i> and <i>Trap</i> mRNA levels in long bones from knockout and control mice (n = 5 (KO) and 8 (FF) independent animals). (B) The <i>Rankl/Opg</i> expression ratio was not modified. (C) N-terminal telopeptides of collagen from serum of 12-weeks-old mice do not display significant differences between control and knockout mice (n = 4 (KO) and 10 (FF) independent animals). (*p<0.05; **p<0.01). (D) TRAP staining of proximal tibiae from FF and KO mice (n = 3 per genotype) showed no differences in osteoclast parameters (N.Oc./B.S., numbers of osteoclast/Bone perimeter; Oc. S./B.S, osteoclast surface/Bone perimeter). Data is presented as means ± SEM. Image shows representative images counterstained with fast green (20× and 40× magnification).