<p>Each panel shows the inferred clonal phylogeny assuming (A) , (B) , (C) and (D) clones, where C0 corresponds to the normal clone. Nodes correspond to inferred clonal populations, and edges are annotated with mutations that occur between the parent and child clones. Two mutations are grouped into a colored box if they both occur on the same branch in all four phylogenies.</p
<p>(A) Mutation prevalences of six mutations in segment 4. (B) Prevalences of the ten associated clo...
The vast majority of mutations in the exome of cancer cells are passengers, which do not affect the ...
Lower panel: Median joining network constructed in program NETWORK. Dashes denote number of mutation...
An accurate phylogeny of a cancer tumour has the potential to shed light on numerous phenomena, such...
(a) The tree inferred by Phertilizer with numbers of SNVs labeled beside the edges, and numbers of c...
<p>A yellow oval, denote a clonal group after applying a similarity index of 90% to PCR typing resul...
A) Number of clones in human tumors within each tumor type. Tumor types are ranked by median number ...
<p>VAFs among the primary and matched metastases in patient A1 (A) and a representative evolutionary...
Intra-tumor heterogeneity presents itself through the evolution of subclones during cancer progressi...
A) Example of Tree score values for phylogenies with 5 clones. The Tree scores increase with increas...
<p>A summary chart of all mutations in each group displays genes across in rows and patient tumors d...
<p>(a) Phylogenetic tree constructed using Bayesian inference. Numbers on branches are posterior pro...
Tumours are composed of multiple subpopulations, each of which has its own genotype and phenotype. ...
<div><p>(A) Multicellular organism development can be represented by a rooted labeled binary tree ca...
(a) The clonal tree inferred by Laks et al. [6] with edges labeled by SNV gains and cell numbers sho...
<p>(A) Mutation prevalences of six mutations in segment 4. (B) Prevalences of the ten associated clo...
The vast majority of mutations in the exome of cancer cells are passengers, which do not affect the ...
Lower panel: Median joining network constructed in program NETWORK. Dashes denote number of mutation...
An accurate phylogeny of a cancer tumour has the potential to shed light on numerous phenomena, such...
(a) The tree inferred by Phertilizer with numbers of SNVs labeled beside the edges, and numbers of c...
<p>A yellow oval, denote a clonal group after applying a similarity index of 90% to PCR typing resul...
A) Number of clones in human tumors within each tumor type. Tumor types are ranked by median number ...
<p>VAFs among the primary and matched metastases in patient A1 (A) and a representative evolutionary...
Intra-tumor heterogeneity presents itself through the evolution of subclones during cancer progressi...
A) Example of Tree score values for phylogenies with 5 clones. The Tree scores increase with increas...
<p>A summary chart of all mutations in each group displays genes across in rows and patient tumors d...
<p>(a) Phylogenetic tree constructed using Bayesian inference. Numbers on branches are posterior pro...
Tumours are composed of multiple subpopulations, each of which has its own genotype and phenotype. ...
<div><p>(A) Multicellular organism development can be represented by a rooted labeled binary tree ca...
(a) The clonal tree inferred by Laks et al. [6] with edges labeled by SNV gains and cell numbers sho...
<p>(A) Mutation prevalences of six mutations in segment 4. (B) Prevalences of the ten associated clo...
The vast majority of mutations in the exome of cancer cells are passengers, which do not affect the ...
Lower panel: Median joining network constructed in program NETWORK. Dashes denote number of mutation...