Translational effect of non-target based resistance to BDQ in mice and inability of verapamil to reverse it.
- Koen Andries (346051)
- Cristina Villellas (596019)
- Nele Coeck (596020)
- Kim Thys (446679)
- Tom Gevers (596021)
- Luc Vranckx (596022)
- Nacer Lounis (355090)
- Bouke C. de Jong (20655)
- Anil Koul (346049)
Publication date
July 2014
DOIAbstract
<p>Log kill values of wild type H37Rv and <i>Rv0678</i> mutants in mice treated with BDQ at 6.25 or 50 mg/kg (5x/week), in the presence (25 V) or absence (0 V) of 25 mg/kg verapamil for 4 weeks. Values represent the median log reduction versus baseline CFU for 6 mice.</p
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