Pancreatic regeneration following acinar injury is impaired in Rag1^−/− mice.

<p>(A) Caerulein injection regime, time of tissue harvesting and schematic depiction of acinar de-differentiation and regeneration following caerulein-induced injury in WT mice. (B and C) Representative H&E staining of pancreas from WT and Rag1^−/− mice treated with PBS control or 2- and 7-days following caerulein-induced injury. (D) Pancreatic immuno-fluorescent staining for CK19, β-catenin and amylase from WT and Rag1^−/− mice at CaeD7. (E and F) Combined and individual scoring of pancreatic histological parameters from WT and Rag1^−/− mice at CaeD2 and CaeD7 (<i>n</i> = 5–20, *P<0.05, **P<0.01, <i>t</i> test).