Expression of MHCII, costimulatory and maturation markers is attenuated in aiDCs.

<p>(A) Expression of surface markers CD1c, CD11b, CD11c, CD14, CD40, CD80 and CD86 on human iDC cultured in the presence of atorvastatin was measured by flow cytometry after the differentiation period (day 7) and compared with surface marker expression of untreated iDC and undifferentiated monocytes from peripheral blood together with isotype controls for untreated iDC and monocytes. The data show relative expression of surface molecules compared to untreated iDC derived from three independent experiments (mean ± SD). (B) Expression of surface markers CD11b, CD11c, CD40, CD80, CD86 and MHC class II of murine iDC cultured in the presence of atorvastatin was measured by flow cytometry after the differentiation period (day 10) and compared with surface marker expression of untreated iDC and isotype controls for untreated iDC. The data show relative expression of surface molecules compared to untreated iDC derived from three independent experiments (mean ± SD).