Robustness analysis against additive white Gaussian noise.

<p>(blue) SNR levels, (light-blue) ground truth, and the number of estimated nuclei for (red) the proposed, (green) previous-1, (purple) previous-2 against increasing noise spreads, when large initial parameters (, , and ) are selected. Note that the proposed method re-estimates a new set of parameters: , , and using feedback mechanism, while previous methods fail to do. A 3D image having 32 nuclei is considered for analysis.