Anti-inflammatory treatment with CORT suppresses enhanced expression of proinflammatory ligands in multiple models of neurotoxicity.

<p>Mice were administered MPTP, METH, or TMT alone or after pretreatment with CORT (20 mg/kg, s.c.) 30 minutes earlier. Mice were killed at 12 hours post dosing. Total RNA was prepared from striatum (MPTP and METH) or hippocampus (TMT) for qRT-PCR analysis of <i>Tnf-α</i>, <i>Osm</i>, <i>Ccl2</i> or <i>Lif</i>. All data points represent mean ± SEM, N = 5. * denotes statistical significance of at least p<0.05 for the neurotoxicant alone or CORT pretreated groups compared to saline controls and # denotes statistical significance of at least p<0.05 for CORT- pretreated groups compared to neurotoxicant only exposed groups. Statistical significance was measured by two-way ANOVA with Fisher's LSD Method of post hoc analysis. See Methods for dosing regimen (single dose METH).