Percentage of patients with somatic mutations at the indicated SNP sites in tumors.

<p>3 <i>CRP</i> SNPs (rs7553007, rs1205, and rs3093077) and 21 additional SNPs of 141 tumor/normal sample pairs were genotyped by Sequenom. These samples were collected from 37 gastric, 12 lung, 27 esophagus, 24 colon and 41 rectal cancer patients. (A) The mutation frequencies at each SNP sites. None of these sites is recurrently mutated in tumors. The frequency of the <i>CRP</i>-286 SNP (rs3091244) mutation in these samples is shown for comparison. (B) The pooled mutation frequencies of SNPs with or without associated genes. Gene-associated SNP sites tend to exhibit lower mutation frequencies albeit without reaching statistical significance (two sample <i>t</i> test, two-tailed, <i>p</i> = 0.47).